Article
Structural diversity of the SARS-CoV-2 Omicron spike.
Molecular cell - 2 Jun 2022
Gobeil Sophie M-C, Henderson Rory, Stalls Victoria, Janowska Katarzyna, Huang Xiao, May Aaron, Speakman Micah, Beaudoin Esther, Manne Kartik, Li Dapeng, Parks Rob, Barr Maggie, Deyton Margaret, Martin Mitchell, Mansouri Katayoun, Edwards Robert J, Eaton Amanda, Montefiori David C, Sempowski Gregory D, Saunders Kevin O, Wiehe Kevin, Williams Wilton, Korber Bette, Haynes Barton F, Acharya Priyamvada
Abstract excerpt
Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV-2 evolution via changes in receptor-binding domain (RBD) and neutralizing antibody epitope presentation, affecting virus transmissibility and immune evasion. Here, we determine cryo-EM structures of the Omicron and Delta spikes to...
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