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Article

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement.

Science (New York, N.Y.) - 25 Feb 2022

McCallum Matthew, Czudnochowski Nadine, Rosen Laura E, Zepeda Samantha K, Bowen John E, Walls Alexandra C, Hauser Kevin, Joshi Anshu, Stewart Cameron, Dillen Josh R, Powell Abigail E, Croll Tristan I, Nix Jay, Virgin Herbert W, Corti Davide, Snell Gyorgy, Veesler David

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern evades antibody-mediated immunity that comes from vaccination or infection with earlier variants due to accumulation of numerous spike mutations. To understand the Omicron antigenic shift, we determined cryo-electron microscopy and x-ray crystal structures of the spike protein and the receptor-binding domain bound to the...

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Share to Angiotensin-Converting Enzyme 2
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Broadly Neutralizing Antibodies

Share to Cryoelectron Microscopy

Share to Immune Evasion

Share to Protein Domains

Share to Protein Interaction Domains and Motifs

Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 35076256
DOI: 10.1126/science.abn8652
PMCID: PMC9427005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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