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Article

Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.

Nature communications - 24 Aug 2022

Zhao Zhennan, Zhou Jingya, Tian Mingxiong, Huang Min, Liu Sheng, Xie Yufeng, Han Pu, Bai Chongzhi, Han Pengcheng, Zheng Anqi, Fu Lutang, Gao Yuanzhu, Peng Qi, Li Ying, Chai Yan, Zhang Zengyuan, Zhao Xin, Song Hao, Qi Jianxun, Wang Qihui, Wang Peiyi, Gao George F

Abstract excerpt

Omicron SARS-CoV-2 is rapidly spreading worldwide. To delineate the impact of emerging mutations on spike's properties, we performed systematic structural analyses on apo Omicron spike and its complexes with human ACE2 or S309 neutralizing antibody (NAb) by cryo-EM. The Omicron spike preferentially adopts the one-RBD-up conformation both before and after ACE2 binding, which is in sharp contrast to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36002453
DOI: 10.1038/s41467-022-32665-7
PMCID: PMC9399999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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