Article

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

2021-12-31

Abstract excerpt

The SARS-CoV-2 Omicron variant of concern evades antibody mediated immunity with an unprecedented magnitude due to accumulation of numerous spike mutations. To understand the Omicron antigenic shift, we determined cryo-electron microscopy and X-ray crystal structures of the spike and RBD bound to the broadly neutralizing sarbecovirus monoclonal antibody (mAb) S309 (the parent mAb of sotrovimab) and to the human AC...

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Literature Corpus work: bda994e9-f005-5a2b-b1b5-56709a297f69
DOI: 10.1101/2021.12.28.474380

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