Article
Genetic variants and polygenic risk scores associated with paroxysmal atrial fibrillation in the Japanese population.
PloS one - 1 Jan 2026
Shiomi Megumi, Nagata Yuki, Sudo Takeaki, Takahashi Kentaro, Higuchi Chihiro, Ihara Kensuke, Asada Ken, Tanaka Yasuaki, Yamauchi Yasuteru, Sasaki Takeshi, Hachiya Hitoshi, Imai Yasushi, Fujita Hideo, Sasano Tetsuo, Furukawa Tetsushi, Tanaka Toshihiro
Abstract excerpt
Early-stage diagnosis of paroxysmal atrial fibrillation (PAF) is challenging owing to its asymptomatic nature. However, the genetic factors underlying PAF and predictive utility of polygenic risk scores (PRSs) for PAF in Asian populations remain elusive. We aimed to explore the PAF-associated genetic variants in a Japanese cohort and evaluate the predictive performance of PAF-specific PRSs. This study included...
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