Article
Genetic Variants Associated With Susceptibility to Atrial Fibrillation in a Japanese Population.
The Canadian journal of cardiology - 1 Apr 2017
Liu Lian, Ebana Yusuke, Nitta Jun-Ichi, Takahashi Yoshihide, Miyazaki Shinsuke, Tanaka Toshihiro, Komura Masatoshi, Isobe Mitsuaki, Furukawa Tetsushi
Abstract excerpt
BACKGROUND: Atrial fibrillation (AF) affects millions of individuals worldwide. The genome-wide association studies have identified robust genetic associations with AF. METHODS: We genotyped 5461 participants of Japanese ancestry for 11 AF-related loci and determined the effects of carrying different numbers of risk alleles on disease development and age at disease onset. The weighted genetic risk score (GRS) was...
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