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Article

Polygenic risk score and clinical factors predict incident idiopathic pulmonary arterial hypertension.

Respiratory medicine - 1 Nov 2025

Hu Song, Tan Jiang-Shan, Zhu Shengsong, Hua Lu, Lin Zhennan, Zhang Jian

Abstract excerpt

BACKGROUND: This study aimed to develop a comprehensive prediction model integrating polygenic risk scores (PRS) and clinical factors to identify individuals at high risk for incident idiopathic pulmonary arterial hypertension (IPAH). METHODS: A PRS was constructed using summary statistics derived from the largest genome-wide association study for pulmonary arterial hypertension in Europeans and validated in the...

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PMID: 41061903
DOI: 10.1016/j.rmed.2025.108404

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