Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting shared genetic architecture between pan-cancer and aging-related traits: a genome-wide cross-trait analysis.

Biogerontology - 4 May 2026

Pu Qiuyi, Wang Chao, Mo Xiaoxiao, Sha Lanlan, Zheng Rui, Zhang Zhengdong, Wu Dongmei

Abstract excerpt

The association between aging and cancer has been extensively documented in observational studies, but their shared genetic basis remains unclear. Leveraging genome-wide association studies summary statistics of aging and pan-cancer (87,531 cases and 314,193 controls) within the European population, genetic correlation and Mendelian randomization analyses were used to estimate genetic correlations, and infer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to TYR gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Neoplasms

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 42081108
DOI: 10.1007/s10522-026-10446-9

Genes

ZC3HC1
CPA5
KLHDC10
TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting shared genetic architecture between pan-cancer and aging-related traits: a genome-wide cross-trait analysis.PMID 42081108Read ↗

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.Semantic proximity Read ↗

Cross-ancestry and phenome-wide associations of cancer-specific polygenic risk scoresSemantic proximity Read ↗

Shared Genetics of Kidney Function Traits and Bladder Cancer: A Genome-Wide Cross-Trait Analysis.Semantic proximity Read ↗

Shared heritability and functional enrichment across six solid cancersSemantic proximity Read ↗

Genome-wide analysis of genetic predisposition to common polygenic cancers.Semantic proximity Read ↗

Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations.Semantic proximity Read ↗

Shared heritability and functional enrichment across six solid cancers.Semantic proximity Read ↗

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.Semantic proximity Read ↗

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.Semantic proximity Read ↗

Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions.Semantic proximity Read ↗

Genomic structural equation modelling of 12 cancers identifies a latent pan-cancer susceptibility factor and shared determinants of carcinogenesis.Semantic proximity Read ↗

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.