Article
Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions.
Journal of the National Cancer Institute - 8 Jun 2023
Lindström Sara, Wang Lu, Feng Helian, Majumdar Arunabha, Huo Sijia, Macdonald James, Harrison Tabitha, Turman Constance, Chen Hongjie, Mancuso Nicholas, Bammler Theo, Gallinger Steve, Gruber Stephen B, Gunter Marc J, Le Marchand Loic, Moreno Victor, Offit Kenneth, De Vivo Immaculata, O'Mara Tracy A, Spurdle Amanda B, Tomlinson Ian, Fitzgerald Rebecca, Gharahkhani Puya, Gockel Ines, Jankowski Janusz, Macgregor Stuart, Schumacher Johannes, Barnholtz-Sloan Jill, Bondy Melissa L, Houlston Richard S, Jenkins Robert B, Melin Beatrice, Wrensch Margaret, Brennan Paul, Christiani David C, Johansson Mattias, Mckay James, Aldrich Melinda C, Amos Christopher I, Landi Maria Teresa, Tardon Adonina, Bishop D Timothy, Demenais Florence, Goldstein Alisa M, Iles Mark M, Kanetsky Peter A, Law Matthew H, Amundadottir Laufey T, Stolzenberg-Solomon Rachael, Wolpin Brian M, Klein Alison, Petersen Gloria, Risch Harvey, Chanock Stephen J, Purdue Mark P, Scelo Ghislaine, Pharoah Paul, Kar Siddhartha, Hung Rayjean J, Pasaniuc Bogdan, Kraft Peter
Abstract excerpt
BACKGROUND: The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci. METHODS: We collected GWAS summary statistics for 12 solid cancers based on 376 759 participants with cancer...
Topics
- Male
- Humans
- Genome-Wide Association Study