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Article

Genome-wide analysis of genetic predisposition to common polygenic cancers.

Journal of applied genetics - 1 May 2022

Nazarian Alireza, Arbeev Konstantin G, Yashkin Arseniy P, Kulminski Alexander M

Abstract excerpt

Lung, breast, prostate, and colorectal cancers are among the most common and fatal malignancies worldwide. They are mainly caused by multifactorial mechanisms and are genetically heterogeneous. We investigated the genetic architecture of these cancers through genome-wide association, pathway-based, and summary-based transcriptome-/methylome-wide association analyses using three independent cohorts. Our...

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Identifiers

PMID: 34981446
DOI: 10.1007/s13353-021-00679-4
PMCID: PMC8983541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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