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Article

Genomic structural equation modelling of 12 cancers identifies a latent pan-cancer susceptibility factor and shared determinants of carcinogenesis.

EBioMedicine - 1 Jul 2026

Xu Qian, Niu Lu, Cao Zian, Geng Jiwen, Yang Huazhen, Zeng Yu, Zhang Yanan, Li Qian, Suo Chen, Yuan Gang, Song Huan, Hou Can

Abstract excerpt

BACKGROUND: Common cancers share germline susceptibility, yet the genetic architecture of a truly pan-cancer component of carcinogenesis remains incompletely resolved. METHODS: We applied genomic structural equation modelling (gSEM) to genome-wide association studies (GWAS) summary statistics for 12 cancers (>600,000 European-ancestry cases) to separate a latent pan-cancer genetic factor from cancer-specific...

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Identifiers

PMID: 42361404
DOI: 10.1016/j.ebiom.2026.106356
PMCID: PMC13325449

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