Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations.

doi:10.1038/s41467-026-71785-2

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Genetic landscape and functional exploration of kidney cancer predisposition in cross-ancestral populations.

Nature communications - 18 Apr 2026

Dai Hongji, Chu Xinlei, Du Han, Yang Shutong, Yao Yanxin, Yu Xinru, Zhao Yanrui, Dong Pei, Lyu Zhangyan, Wang Wei, Li Haixin, Mi Zeyun, Sheng Chao, Li Xiangchun, Zheng Hong, Song Fangfang, Song Fengju, Sun Menghong, Dai Juncheng, Lan Qing, Rothman Nathaniel, Hu Zhibin, Wei Qingyi, Ye Dingwei, Yao Xin, Jia Weihua, Chanock Stephen J, Shen Hongbing, Purdue Mark P, Li Mulin Jun, Chen Kexin

Abstract excerpt

Renal cell carcinoma (RCC) is the most common type of kidney cancer, but its genetic architecture has not been fully characterized, particularly in Asian populations. Here, we perform a multi-ancestry meta-analysis of 33,712 RCC cases and 845,786 controls, including individuals of East Asian (5,313 cases and 96,912 controls), European (25,890 cases and 743,585 controls), African American (897 cases and 3,109...

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PMID: 42000752
DOI: 10.1038/s41467-026-71785-2
PMCID: PMC13275800

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