Cross-Ancestry and Phenome-Wide Associations of Cancer-Specific Polygenic Risk Scores.

doi:10.1200/PO-25-00957

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Article

Cross-Ancestry and Phenome-Wide Associations of Cancer-Specific Polygenic Risk Scores.

JCO precision oncology - 1 Sept 2026

Wang Louise, Desai Heena, Teerlink Craig, Clark Oliver, Pridgen Kathryn M, Lee Jennifer, Chang Kyong-Mi, Kember Rachel L, Vujkovic Marijana, Lynch Julie A, Maxwell Kara N

Abstract excerpt

PURPOSE: Genome-wide association studies have identified many common variants associated at low effect sizes with various cancers. Summing the effects of these variants into polygenic risk scores (PRS) can improve cancer risk prediction. However, cross-cancer and cross-phenotype pleiotropic associations of cancer-specific PRS are limited. METHODS: Using logistic regression models, we tested the association of 13...

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Topics

Female
Humans
Male
Middle Aged
Genetic Predisposition to Disease
Genetic Risk Score

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Multifactorial Inheritance

Neoplasms

Phenomics

Phenotype

Black or African American

White

Source

Open in PubMed

Identifiers

PMID: 42753222
DOI: 10.1200/PO-25-00957

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