Article

Cross-ancestry and phenome-wide associations of cancer-specific polygenic risk scores

2025-05-16

Abstract excerpt

<h4>Background</h4> Genome-wide association studies (GWAS) have identified many common variants associated at low effect sizes with various cancers. Summing the effects of these variants into polygenic risk scores (PRS) can improve cancer risk prediction. However, these PRS have largely been analyzed in cohorts restricted to individuals of European descent, and research into potential cross-cancer and cross-phenot...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac2cf232-f654-5c47-95ad-418798fd5d21
DOI: 10.1101/2025.05.15.25327704

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross-ancestry and phenome-wide associations of cancer-specific polygenic risk scoresDOI 10.1101/2025.05.15.25327704Read

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.Semantic proximity Read

On Cross-ancestry Cancer Polygenic Risk ScoresSemantic proximity Read

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.Semantic proximity Read

On cross-ancestry cancer polygenic risk scores.Semantic proximity Read

Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions.Semantic proximity Read

Shared heritability and functional enrichment across six solid cancersSemantic proximity Read

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.Semantic proximity Read

Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobankSemantic proximity Read

Evaluating polygenic risk scores in assessing risk of nine solid and hematologic cancers in European descendants.Semantic proximity Read

Shared heritability and functional enrichment across six solid cancers.Semantic proximity Read

Ancestry-Specific Predisposing Germline Variants in CancerSemantic proximity Read

Quantifying the Genetic Correlation between Multiple Cancer Types.Semantic proximity Read