Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.

doi:10.1038/s41467-020-18246-6

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Article

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.

Nature communications - 4 Sept 2020

Rashkin Sara R, Graff Rebecca E, Kachuri Linda, Thai Khanh K, Alexeeff Stacey E, Blatchins Maruta A, Cavazos Taylor B, Corley Douglas A, Emami Nima C, Hoffman Joshua D, Jorgenson Eric, Kushi Lawrence H, Meyers Travis J, Van Den Eeden Stephen K, Ziv Elad, Habel Laurel A, Hoffmann Thomas J, Sakoda Lori C, Witte John S

Abstract excerpt

Deciphering the shared genetic basis of distinct cancers has the potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we undertake genome-wide association studies (GWAS) and comprehensive evaluations of heritability and pleiotropy across 18 cancer types in two large, population-based cohorts: the UK Biobank (408,786 European ancestry individuals; 48,961...

Topics

Adult
Aged
Carcinogenesis
Case-Control Studies
Female
Genetic Pleiotropy
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neoplasms

Polymorphism, Single Nucleotide

Risk Assessment

Risk Factors

White People

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Identifiers

PMID: 32887889
DOI: 10.1038/s41467-020-18246-6
PMCID: PMC7473862

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