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Article

Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells.

Cell - 25 Jun 2026

Lyu Peng, Agarwal Gaurav, Guo Chun-Jie, Sychla Adam, Bourgeois Wallace, Ye Tianyi, Weng Chen, Antoszewski Mateusz, Joubran Samantha, Caulier Alexis, Poeschla Michael, Armstrong Scott A, Rouskin Silvi, Sankaran Vijay G

Abstract excerpt

The HOXA gene locus coordinates body patterning, hematopoiesis, and differentiation. While studying blood phenotype-associated variation within the HOXA locus, we identified a genetic variant, rs17437411, associated with globally reduced blood counts, protection from blood cancers, and variation in anthropometric phenotypes. We found that this variant disrupts the activity of a previously unstudied antisense long...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 42068976
DOI: 10.1016/j.cell.2026.04.014
PMCID: PMC13138457

Genes

HOXA9
HOXA7
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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