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Article

Sequence variants affecting fetal globin expression pointing to potential drug targets

2026-06-08

Abstract excerpt

<title>Abstract</title> <p>High fetal hemoglobin level is the most important predictor of favorable clinical outcome in sickle cell disease. We carried out a genome-wide association study (GWAS) on estimated fetal beta globin RNA expression ratio (FGR) using blood RNA sequence data from 22,093 adult Icelanders. In addition to the well-known BCL11A, HBB/HBG2 and HBS1L-MYB loci, we found 33 loci associated with FGR...

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Literature Corpus work
e994c810-a1ee-54c7-8368-e47fd6dc53a2
DOI
10.21203/rs.3.rs-9225158/v1
Open publication

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Sequence variants affecting fetal globin expression pointing to potential drug targetsDOI 10.21203/rs.3.rs-9225158/v1
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