Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10p21.2.

doi:10.1038/ncomms14616

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Article

Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10p21.2.

Nature communications - 3 Mar 2017

Studd James B, Vijayakrishnan Jayaram, Yang Minjun, Migliorini Gabriele, Paulsson Kajsa, Houlston Richard S

Abstract excerpt

Despite high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) being the most common subgroup of paediatric ALL, its aetiology remains unknown. Genome-wide association studies have demonstrated association at 10q21.2. Here, we sought to determine how this region influences HD-ALL risk. We impute genotypes across the locus, finding the single nucleotide polymorphism rs7090445 highly associated with HD-ALL...

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Share to Chromosomes, Human, Pair 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 3 Subunit

Share to Diploidy

Share to Enhancer Elements, Genetic

Share to Gene Expression Regulation, Leukemic

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Sequence Analysis, RNA

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PMID: 28256501
DOI: 10.1038/ncomms14616
PMCID: PMC5337971

Genes

RUNX3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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