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Article

The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNA HOTAIR via a novel intronic enhancer.

Carcinogenesis - 1 Sept 2014

Zhang Xiaojiao, Zhou Liqing, Fu Guobin, Sun Fang, Shi Juan, Wei Jinyu, Lu Chao, Zhou Changchun, Yuan Qipeng, Yang Ming

Abstract excerpt

Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR), which could induce genome-wide retargeting of polycomb-repressive complex 2, trimethylates histone H3 lysine-27 (H3K27me3) and deregulation of multiple downstream genes, is involved in development and progression of esophageal squ...

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Share to Carcinoma, Squamous Cell
Share to Cell Line, Tumor
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Neoplasms

Share to Esophageal Squamous Cell Carcinoma

Share to Gene Expression Regulation, Neoplastic

Share to Introns

Share to RNA, Long Noncoding

Source

Identifiers

PMID: 24788237
DOI: 10.1093/carcin/bgu103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24788237-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Association on polymorphisms in LncRNA HOTAIR and susceptibility to HNSCC in Chinese population.Semantic proximity Read ↗

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