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Article

HOXA9 transcription factor is a double-edged sword: from development to cancer progression

8 Dec 2023

Abstract excerpt

The HOXA9 transcription factor serves as a molecular orchestrator in cancer stemness, epithelial-mesenchymal transition (EMT), metastasis, and generation of the tumor microenvironment in hematological and solid malignancies. However, the multiple modes of regulation, multifaceted functions, and context-dependent interactions responsible for the dual role of HOXA9 as an oncogene or tumor suppressor in cancer...

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PMID: 38062297
DOI: 10.1007/s10555-023-10159-2

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