Article

Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells

2025-07-16

Abstract excerpt

The HOXA gene locus coordinates body patterning, hematopoiesis, and differentiation. While studying blood phenotype-associated variation within the HOXA locus, we identified a genetic variant, rs17437411, associated with globally reduced blood counts, protection from blood cancers, and variation in anthropometric phenotypes. We find that this variant disrupts the activity of a previously unstudied antisense long n...

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Literature Corpus work: c2d8c6af-7924-52f7-a59c-d962a1e81644
DOI: 10.1101/2025.07.16.664824

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