Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT.

Nature communications - 1 May 2026

Li Haikuo, Tao Bo, Enninful Archibald, Zhang Dingyao, Dai Yi, Oh Fiona, Farzad Negin, Li Keyi, Bai Zhiliang, Qin Xiaoyu, Yang Mingyu, Hwang Emily J, Zhang Jing, Lu Jun, Gerstein Mark, Zhou Jingtian, Xu Mina L, Fan Rong

Abstract excerpt

While formalin-fixed paraffin-embedded (FFPE) samples are invaluable for human non-Hodgkin B-cell lymphoma translational research, effective methods for spatial profiling of chromatin accessibility and histone modifications in these tissues remain limited. Here, we introduce epi-Patho-DBiT, a platform that combines reverse crosslinking of FFPE tissues with spatially resolved assays for transposase-accessible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Formaldehyde

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Lymphoma

Share to Lymphoma, Follicular

Share to Lymphoma, Large B-Cell, Diffuse

Share to Paraffin Embedding

Share to Tissue Fixation

Source

Open in PubMed Open full text

Identifiers

PMID: 42067542
DOI: 10.1038/s41467-026-71576-9
PMCID: PMC13338050

Genes

DIP2C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatially decoding genotype-associated epigenetic landscapes in human lymphoma FFPE tissues via epi-Patho-DBiT.PMID 42067542Read ↗

Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsiesSemantic proximity Read ↗

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustionSemantic proximity Read ↗

Robust estimation of cancer and immune cell-type proportions from bulk tumor ATAC-Seq dataSemantic proximity Read ↗

Epigenomic Characterization of Lymphoid Neoplasms.Semantic proximity Read ↗

RNA Polymerase II hypertranscription at histone genes in cancer FFPE samplesSemantic proximity Read ↗

Somatic epimutations cap genetic determinism in the human diploid chromatin epigenomeSemantic proximity Read ↗

Profiling chromatin accessibility in formalin-fixed paraffin-embedded samplesSemantic proximity Read ↗

Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma.Semantic proximity Read ↗

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineagesSemantic proximity Read ↗

Spatially Exploring RNA Biology in Archival Formalin-Fixed Paraffin-Embedded TissuesSemantic proximity Read ↗

Tracing cancer evolution and heterogeneity using Hi-CSemantic proximity Read ↗

Robust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.