Article

Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

2019-04-18

Abstract excerpt

Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here we present a massively parallel droplet-based platform for mapping transposase-accessible chromatin in tens of thousands of single cells per sample (scATAC-seq). We obtain and analyze chromatin profiles of over 200,000 single cells in two primary human systems. In blood, scATAC-seq allows marker-free...

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Literature Corpus work: a0ab00c6-47c5-5bd9-941f-8d9c184c866f
DOI: 10.1101/610550

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