Article

RNA Polymerase II hypertranscription at histone genes in cancer FFPE samples

2024-03-03

Abstract excerpt

Genome-wide hypertranscription is common in hu-man cancer and predicts poor prognosis. To under-stand how hypertranscription might drive cancer, we applied our FFPE-CUTAC method for mapping RNA Polymerase II (RNAPII) genome-wide in formalin-fixed paraffin-embedded (FFPE) sections. We demonstrate global RNAPII elevations in mouse gliomas and assort-ed human tumors in small clinical samples and discov-er regional el...

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Literature Corpus work: 44cd9adb-97eb-5409-aab3-6e7251130829
DOI: 10.1101/2024.02.28.582647

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