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Identification of JAZF1, KNOP1, and PLEKHA1 as causally associated genes and drug targets for Alzheimer's disease: a summary data-based Mendelian randomization study.

Inflammopharmacology - 1 Dec 2024

Zhai Yuhan, Li Ning, Zhang Yujie, Li Haibin, Wu Lijuan, Wei Cuibai, Ji Jianguang, Zheng Deqiang

Abstract excerpt

BACKGROUND: There is a growing body of evidence indicating the significant role of the immune system and immune cells in the progression of Alzheimer's disease (AD). However, the exact role of genes from various immune cell types in AD remains unclear. We aimed to utilize summary data-based Mendelian randomization (SMR) to explore the potential causal relationships between genes in specific immune cells and the...

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PMID: 39455528
DOI: 10.1007/s10787-024-01583-z

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