Article
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women.
Nature communications - 31 Jul 2020
Ho Weang-Kee, Tan Min-Min, Mavaddat Nasim, Tai Mei-Chee, Mariapun Shivaani, Li Jingmei, Ho Peh-Joo, Dennis Joe, Tyrer Jonathan P, Bolla Manjeet K, Michailidou Kyriaki, Wang Qin, Kang Daehee, Choi Ji-Yeob, Jamaris Suniza, Shu Xiao-Ou, Yoon Sook-Yee, Park Sue K, Kim Sung-Won, Shen Chen-Yang, Yu Jyh-Cherng, Tan Ern Yu, Chan Patrick Mun Yew, Muir Kenneth, Lophatananon Artitaya, Wu Anna H, Stram Daniel O, Matsuo Keitaro, Ito Hidemi, Chan Ching Wan, Ngeow Joanne, Yong Wei Sean, Lim Swee Ho, Lim Geok Hoon, Kwong Ava, Chan Tsun L, Tan Su Ming, Seah Jaime, John Esther M, Kurian Allison W, Koh Woon-Puay, Khor Chiea Chuen, Iwasaki Motoki, Yamaji Taiki, Tan Kiak Mien Veronique, Tan Kiat Tee Benita, Spinelli John J, Aronson Kristan J, Hasan Siti Norhidayu, Rahmat Kartini, Vijayananthan Anushya, Sim Xueling, Pharoah Paul D P, Zheng Wei, Dunning Alison M, Simard Jacques, van Dam Rob Martinus, Yip Cheng-Har, Taib Nur Aishah Mohd, Hartman Mikael, Easton Douglas F, Teo Soo-Hwang, Antoniou Antonis C
Abstract excerpt
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to...
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