Article
Polygenic risk scores for prediction of breast cancer risk in Asian populations.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Mar 2022
Ho Weang-Kee, Tai Mei-Chee, Dennis Joe, Shu Xiang, Li Jingmei, Ho Peh Joo, Millwood Iona Y, Lin Kuang, Jee Yon-Ho, Lee Su-Hyun, Mavaddat Nasim, Bolla Manjeet K, Wang Qin, Michailidou Kyriaki, Long Jirong, Wijaya Eldarina Azfar, Hassan Tiara, Rahmat Kartini, Tan Veronique Kiak Mien, Tan Benita Kiat Tee, Tan Su Ming, Tan Ern Yu, Lim Swee Ho, Gao Yu-Tang, Zheng Ying, Kang Daehee, Choi Ji-Yeob, Han Wonshik, Lee Han-Byoel, Kubo Michiki, Okada Yukinori, Namba Shinichi, Park Sue K, Kim Sung-Won, Shen Chen-Yang, Wu Pei-Ei, Park Boyoung, Muir Kenneth R, Lophatananon Artitaya, Wu Anna H, Tseng Chiu-Chen, Matsuo Keitaro, Ito Hidemi, Kwong Ava, Chan Tsun L, John Esther M, Kurian Allison W, Iwasaki Motoki, Yamaji Taiki, Kweon Sun-Seog, Aronson Kristan J, Murphy Rachel A, Koh Woon-Puay, Khor Chiea-Chuen, Yuan Jian-Min, Dorajoo Rajkumar, Walters Robin G, Chen Zhengming, Li Liming, Lv Jun, Jung Keum-Ji, Kraft Peter, Pharoah Paul D B, Dunning Alison M, Simard Jacques, Shu Xiao-Ou, Yip Cheng-Har, Taib Nur Aishah Mohd, Antoniou Antonis C, Zheng Wei, Hartman Mikael, Easton Douglas F, Teo Soo-Hwang
Abstract excerpt
PURPOSE: Non-European populations are under-represented in genetics studies, hindering clinical implementation of breast cancer polygenic risk scores (PRSs). We aimed to develop PRSs using the largest available studies of Asian ancestry and to assess the transferability of PRS across ethnic subgroups. METHODS: The development data set comprised 138,309 women from 17 case-control studies. PRSs were generated using...
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