Article
Development and validation of genome-wide polygenic risk scores for predicting breast cancer incidence in Japanese females: a population-based case-cohort study.
Breast cancer research and treatment - 1 Feb 2023
Ohbe Hiroyuki, Hachiya Tsuyoshi, Yamaji Taiki, Nakano Shiori, Miyamoto Yoshihisa, Sutoh Yoichi, Otsuka-Yamasaki Yayoi, Shimizu Atsushi, Yasunaga Hideo, Sawada Norie, Inoue Manami, Tsugane Shoichiro, Iwasaki Motoki
Abstract excerpt
PURPOSE: This study aimed to develop an ancestry-specific polygenic risk scores (PRSs) for the prediction of breast cancer events in Japanese females and validate it in a longitudinal cohort study. METHODS: Using publicly available summary statistics of female breast cancer genome-wide association study (GWAS) of Japanese and European ancestries, we, respectively, developed 31 candidate genome-wide PRSs using...
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