CD38 genotype-dependent regulation of CD44 and TP53 links genetic variation to aggressive phenotype in chronic lymphocytic leukemia.

doi:10.36740/Merkur202602101

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CD38 genotype-dependent regulation of CD44 and TP53 links genetic variation to aggressive phenotype in chronic lymphocytic leukemia.

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego - 1 Jan 2026

Hussain Maryam A, Amer Maggie E, El-Ashwah Shaimaa, ElKosairy Motaz, El-Sherbini Yasser M, Mabed Mohamed, Abdraboh Mohamed E

Abstract excerpt

OBJECTIVE: Aim: To estimate role of CD38 rs6449182 polymorphism in CLL risk and its effect on the expression of critical tumor suppressor TP53, the promoter of cell adhesion and migration, CD44, and the immune checkpoint molecule PD-L1. PATIENTS AND METHODS: Materials and Methods: This case-control study included 50 CLL patients and 50 healthy individuals, age- and sex-matched. CLL diagnosed by flow cytometry...

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Identifiers

PMID: 42048498
DOI: 10.36740/Merkur202602101

Genes

CD38
CD44
TP53
CD19
CD5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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