The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia.

doi:10.1016/j.leukres.2007.10.003

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia.

Leukemia research - 1 Jun 2008

Kaderi Mohd Arifin, Murray Fiona, Jansson Mattias, Merup Mats, Karlsson Karin, Roos Göran, Aleskog Anna, Tobin Gerard

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with no known single predisposing genetic factor shown in all cases. Recently, a single nucleotide polymorphism (SNP) T393C in the GNAS1 gene has been reported to have a clinical impact on CLL progression and overall survival. In order to further investigate the T393C SNP in CLL, we have genotyped 279 CLL cases and correlated the genotypes...

Topics

ADP-ribosyl Cyclase 1
Aged
Chromogranins
Cohort Studies
DNA Primers
Disease Progression
GTP-Binding Protein alpha Subunits, Gs
Gene Expression Regulation, Leukemic
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Heavy Chains

Immunoglobulin Variable Region

Leukemia, Lymphocytic, Chronic, B-Cell

Mutation

Polymorphism, Single Nucleotide

Prognosis

RNA, Messenger

Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 18006055
DOI: 10.1016/j.leukres.2007.10.003

Genes

GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia.PMID 18006055Read ↗

The GNAS1 T393C polymorphism is associated with disease progression and survival in chronic lymphocytic leukemia.Semantic proximity Read ↗

The T393C polymorphism in the gene GNAS1 of G protein is associated with survival of patients with invasive breast carcinoma.Semantic proximity Read ↗

GNAS1 T393C polymorphism and survival in patients with sporadic colorectal cancer.Semantic proximity Read ↗

CD38 gene polymorphisms contribute to genetic susceptibility to B-cell chronic lymphocytic leukemia: evidence from two case-control studies in Polish Caucasians.Semantic proximity Read ↗

CD38 genotype-dependent regulation of CD44 and TP53 links genetic variation to aggressive phenotype in chronic lymphocytic leukemia.Semantic proximity Read ↗

Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?Semantic proximity Read ↗

Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer.Semantic proximity Read ↗

The CC genotype of the C825T polymorphism of the G protein beta3 gene (GNB3) is associated with a high relapse rate in patients with chronic lymphocytic leukaemia.Semantic proximity Read ↗

Interleukin-10-1082A>G (rs1800896) Single Nucleotide Polymorphism is Not a Risk Factor of Chronic Lymphocytic Leukemia in Sudanese Population.Semantic proximity Read ↗

Vascular endothelial growth factor A (VEGFA) gene polymorphisms have an impact on survival in a subgroup of indolent patients with chronic lymphocytic leukemia.Semantic proximity Read ↗

CD38 gene polymorphism and risk of chronic lymphocytic leukemia.Semantic proximity Read ↗

Relationship between ARLTS1 polymorphisms and risk of chronic lymphocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.