Article
The GNAS1 T393C polymorphism and lack of clinical prognostic value in chronic lymphocytic leukemia.
Leukemia research - 1 Jun 2008
Kaderi Mohd Arifin, Murray Fiona, Jansson Mattias, Merup Mats, Karlsson Karin, Roos Göran, Aleskog Anna, Tobin Gerard
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease with no known single predisposing genetic factor shown in all cases. Recently, a single nucleotide polymorphism (SNP) T393C in the GNAS1 gene has been reported to have a clinical impact on CLL progression and overall survival. In order to further investigate the T393C SNP in CLL, we have genotyped 279 CLL cases and correlated the genotypes...
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