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Article

Dual role of the CXCL12 polymorphism in patients with chronic lymphocytic leukemia.

HLA - 1 Jun 2016

Butrym A, Gebura K, Iwaszko M, Kuliczkowski K, Bogunia-Kubik K, Mazur G

Abstract excerpt

The CXCL12 [chemokine (C-X-C motif) ligand 12] is a member of the CXC family of chemokines and interacts with its CXCR4 receptor. The CXCL12/CXCR4 axis is involved in regulation of proliferation, survival and trafficking of hematopoietic stem cells, including B lymphocytes and disruption within this signaling pathway has been implicated in pathogenesis of chronic lymphocytic leukemia (CLL). The aim of this study...

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Topics

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Share to ADP-ribosyl Cyclase 1
Share to Antigens, Differentiation, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to B-Lymphocytes

Share to Chemokine CXCL12

Share to Histocompatibility Antigens Class II

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Neoplasm Grading

Share to Receptors, CXCR4

Source

Identifiers

PMID: 27173875
DOI: 10.1111/tan.12810

Genes

CXCL12
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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