Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical relevance of TP53 polymorphic genetic variations in chronic lymphocytic leukemia.

Leukemia research - 1 Jul 2017

Bilous Nadiia, Abramenko Iryna, Saenko Vladimir, Chumak Anatoliy, Dyagil Iryna, Martina Zoya, Kryachok Iryna

Abstract excerpt

OBJECTIVES: To analyze the distribution of single nucleotide polymorphisms (SNPs) in the TP53 gene in chronic lymphocytic leukemia (CLL) patients and to evaluate their associations with clinical behavior of the disease. METHODS: SNPs in exons and parts of adjacent introns of the TP53 gene were analyzed in 235 CLL patients observed during 2005-2012 years. Data on individuals of European descent from the 1000...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Biomarkers, Tumor
Share to Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kaplan-Meier Estimate

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Prognosis

Share to Proportional Hazards Models

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 28364582
DOI: 10.1016/j.leukres.2017.03.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical relevance of TP53 polymorphic genetic variations in chronic lymphocytic leukemia.PMID 28364582Read ↗

TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia.Semantic proximity Read ↗

TP53 Gene 72 Arg/Pro (rs1042522) single nucleotide polymorphism increases the risk and the severity of chronic lymphocytic leukemiaSemantic proximity Read ↗

TP53 Pro72 allele potentially increases the poor prognostic significance of TP53 mutation in chronic lymphocytic leukemia.Semantic proximity Read ↗

TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations.Semantic proximity Read ↗

Landscape of TP53 Alterations in Chronic Lymphocytic Leukemia via Data Mining Mutation DatabasesSemantic proximity Read ↗

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-2024 update.Semantic proximity Read ↗

Relevance of TP53 for CLL diagnosticsSemantic proximity Read ↗

A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples.Semantic proximity Read ↗

Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up.Semantic proximity Read ↗

Genetic variability profiling of the p53 signaling pathway in chronic lymphocytic leukemia. Individual and combined analysis of TP53, MDM2 and NQO1 gene variants.Semantic proximity Read ↗

Two germ line polymorphisms of the tumour suppressor gene p53 may influence the biology of chronic lymphocytic leukaemia.Semantic proximity Read ↗

Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.