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Genetic variability profiling of the p53 signaling pathway in chronic lymphocytic leukemia. Individual and combined analysis of TP53, MDM2 and NQO1 gene variants.

Annals of hematology - 1 Dec 2024

Fontecha María Belén, Anadón María Del Rosario, Mercado Guzmán Verónica, Stanganelli Carmen, Galvano Camila, Tosin Fernanda, Bordone Javier, Bezares Raimundo, Rodríguez Cecilia, Heller Viviana, Slavutsky Irma, Fundia Ariela Freya

Abstract excerpt

TP53 gene disruption, including 17p13 deletion [del(17p)] and/or TP53 mutations, is a negative prognostic biomarker in chronic lymphocytic leukemia (CLL) associated with disease progression, treatment failure and shorter survival. Germline variants in p53 signaling pathway genes could also lead to p53 dysfunction, but their involvement in CLL has not been thoroughly evaluated. The aim of this study was to...

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PMID: 38743086
DOI: 10.1007/s00277-024-05794-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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