Article
CD38 gene polymorphisms contribute to genetic susceptibility to B-cell chronic lymphocytic leukemia: evidence from two case-control studies in Polish Caucasians.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2009
Jamroziak Krzysztof, Szemraj Zofia, Grzybowska-Izydorczyk Olga, Szemraj Janusz, Bieniasz Magdalena, Cebula Barbara, Giannopoulos Krzysztof, Balcerczak Ewa, Jesionek-Kupnicka Dorota, Kowal Malgorzata, Kostyra Aleksandra, Calbecka Malgorzata, Wawrzyniak Ewa, Mirowski Marek, Kordek Radzislaw, Robak Tadeusz
Abstract excerpt
Given the recent findings on the importance of CD38 signaling in the pathogenesis of B-cell chronic lymphocytic leukemia (B-CLL), we hypothesized that single nucleotide polymorphisms (SNP) in the CD38 gene may be related to B-CLL risk. We evaluated two potentially functional CD38 SNPs, intronic rs6449182 (184C>G) and missense rs1800561 (418C>T, Arg140Trp) in two hospital-based case-control studies (study A and...
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