Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two germ line polymorphisms of the tumour suppressor gene p53 may influence the biology of chronic lymphocytic leukaemia.

Leukemia research - 1 Sept 2006

Kochethu Geothy, Delgado Julio, Pepper Chris, Starczynski Jane, Hooper Laura, Krishnan Satish, Fegan Christopher, Pratt Guy

Abstract excerpt

Chronic lymphocytic leukaemia (CLL) is characterised by the accumulation of mature B lymphocytes. Defects in the tumour suppressor gene p53 pathway are known to be important in CLL and p53 inactivation is associated with a particularly aggressive form of CLL. A single nucleotide polymorphism (SNP) in codon 72 of TP53 leads to a single amino acid change leading to a change in apoptotic potential and alters...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Introns

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Polymorphism, Restriction Fragment Length

Share to Survival Rate

Source

Identifiers

PMID: 16458962
DOI: 10.1016/j.leukres.2005.12.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two germ line polymorphisms of the tumour suppressor gene p53 may influence the biology of chronic lymphocytic leukaemia.PMID 16458962Read ↗

TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia.Semantic proximity Read ↗

In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis.Semantic proximity Read ↗

TP53 Gene 72 Arg/Pro (rs1042522) single nucleotide polymorphism increases the risk and the severity of chronic lymphocytic leukemiaSemantic proximity Read ↗

TP53 Pro72 allele potentially increases the poor prognostic significance of TP53 mutation in chronic lymphocytic leukemia.Semantic proximity Read ↗

Clinical relevance of TP53 polymorphic genetic variations in chronic lymphocytic leukemia.Semantic proximity Read ↗

CD38 genotype-dependent regulation of CD44 and TP53 links genetic variation to aggressive phenotype in chronic lymphocytic leukemia.Semantic proximity Read ↗

Variation in the human TP53 gene affects old age survival and cancer mortality.Semantic proximity Read ↗

The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform.Semantic proximity Read ↗

Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population.Semantic proximity Read ↗

p53 pathway gene single nucleotide polymorphisms and chronic lymphocytic leukemia.Semantic proximity Read ↗

p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis.Semantic proximity Read ↗

Common polymorphism G(-248)A in the promoter region of the bax gene results in significantly shorter survival in patients with chronic lymphocytic Leukemia once treatment is initiated.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.