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Article

CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?

Blood - 15 Jun 2008

Aydin Semra, Rossi Davide, Bergui Luciana, D'Arena Giovanni, Ferrero Enza, Bonello Lisa, Omedé Paola, Novero Domenico, Morabito Fortunato, Carbone Antonino, Gaidano Gianluca, Malavasi Fabio, Deaglio Silvia

Abstract excerpt

CD38 rules proliferation signals in chronic lymphocytic leukemia (CLL) cells, suggesting that the molecule is not merely a prognostic marker but also a key element in the pathogenetic network underlying the disease. CD38 has a genetic polymorphism, characterized by a C>G variation in the regulatory region of intron 1. The working hypothesis is that the presence of different alleles in CLL patients marks (or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Lymphoma, Large B-Cell, Diffuse

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Source

Identifiers

PMID: 18424664
DOI: 10.1182/blood-2008-01-129726

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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