Article
Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors.
Blood - 15 Aug 2002
Oscier David G, Gardiner Anne C, Mould Sarah J, Glide Sharron, Davis Zadie A, Ibbotson Rachel E, Corcoran Martin M, Chapman Robert M, Thomas Peter W, Copplestone J Adrian, Orchard Jenny A, Hamblin Terry J
Abstract excerpt
This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology, CD38 expression, and IGVH gene status in 205 patients with chronic lymphocytic leukemia (B-CLL). Deletion of chromosome 11q23, absence of a deletion of chromosome 13q14, atypical lymphocyte morphology, and more than 30% CD38 expression are significantly...
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