Pathway-level somatic mutation burden reflects diffuse genomic accumulation rather than selective transcriptional disruption in ovarian serous carcinoma: Evidence from bulk, spatial, and multi-region genomic analyses.

Abstract excerpt

OBJECTIVE: Whether increasing tumor mutation burden (TMB) drives selective transcriptional pathway disruption or reflects diffuse genomic accumulation in ovarian serous carcinoma remains unclear. METHODS: TMB-transcriptome relationships were examined in the CPTAC-GDC cohort (n = 84) using Spearman correlations between continuous TMB and ssGSEA-derived Hallmark pathway scores. Pathway-level somatic mutations were...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cohort Studies
• Share to Cystadenocarcinoma, Serous