Germline BRCA1/2-associated multi-omic landscape in High Grade Serous Ovarian Cancer (HGSOC): insights from the PowerOMICS study

Abstract excerpt

Germline BRCA1/2 mutations are prevalent in high-grade serous ovarian carcinoma (HGSOC) and influence tumor biology and treatment response. Although the genomic consequences of homologous recombination repair (HR) deficiency are well established, the integrated multi-omic landscape characterizing tumors carrying these germline variants remains incompletely characterized. In the novel prospective Polish PowerOMICS...

Topics

Open a Topic to create a Post that cites this publication.

• BRCA gene mutations in cancer
• Ovarian cancer diagnosis and treatment
• PARP inhibition in cancer therapy

Identifiers and source

Literature Corpus work

7447f5c1-c5fd-5808-bc2c-c11447b220b5

DOI

10.1186/s10020-026-01614-1