Back to search

Article

Deciphering Spatially Resolved Pathway Heterogeneity in Ovarian Cancer Post-Neoadjuvant Chemotherapy

2025-08-12

Abstract excerpt

High-grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian cancer, characterized by high recurrence rates and limited treatment options following chemotherapy resistance. Its significant heterogeneity poses major challenges for effective therapy and clinical outcomes. In this study, we present a systems-level analysis of spatial transcriptomics data to characterize tumor heterogeneit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
832c10a8-e9d0-55a5-9e3e-a625f96148cb
DOI
10.1101/2025.08.08.669449
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Deciphering Spatially Resolved Pathway Heterogeneity in Ovarian Cancer Post-Neoadjuvant ChemotherapyDOI 10.1101/2025.08.08.669449
Integrated analysis of spatial transcriptomics and CT phenotypes for unveiling the novel molecular characteristics of recurrent and non-recurrent high-grade serous ovarian cancerSemantic proximity
Effect of fibroblast heterogeneity on prognosis and drug resistance in high-grade serous ovarian cancerSemantic proximity
Single‐cell transcriptomes reveal heterogeneity of high‐grade serous ovarian carcinomaSemantic proximity
Decoding the effect of fibroblast heterogeneity on prognosis and drug resistance in high-grade serous ovarian cancer through tumor evolution analysisSemantic proximity
Decoding the impact of fibroblast heterogeneity on prognosis and drug resistance in high-grade serous ovarian cancer through tumor evolution analysisSemantic proximity
Characterizing intra- and inter-tumor heterogeneity in Ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomicsSemantic proximity
Integrating Genomic, Epigenomic, and Transcriptomic Features Reveals Modular Signatures Underlying Poor Prognosis in Ovarian CancerSemantic proximity
Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune microenvironmentSemantic proximity
Immune cell landscapes are associated with high-grade serous ovarian cancer survivalSemantic proximity
Neoadjuvant Chemotherapy Modulates the Tumor Microenvironment in High-Grade Serous Ovarian CancerSemantic proximity
Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancerSemantic proximity
Spatial transcriptomics reveals ovarian cancer subclones with distinct tumour microenvironmentsSemantic proximity
Select a neighboring publication to make it the new centre.