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Deciphering ovarian cancer heterogeneity through spatial transcriptomics, single-cell profiling, and copy number variations

4 Mar 2025

Abstract excerpt

High-grade serous ovarian carcinoma (HGSOC) poses a formidable clinical challenge due to multidrug resistance (MDR) caused by tumor heterogeneity. To elucidate the intricate mechanisms underlying HGSOC heterogeneity, we conducted a comprehensive analysis of five single-cell transcriptomes and eight spatial transcriptomes derived from eight HGSOC patients. This study provides a comprehensive view of tumor...

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PMID: 40036264
DOI: 10.1371/journal.pone.0317115

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