Article
Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition.
Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2016
Zhao Siming, Bellone Stefania, Lopez Salvatore, Thakral Durga, Schwab Carlton, English Diana P, Black Jonathan, Cocco Emiliano, Choi Jungmin, Zammataro Luca, Predolini Federica, Bonazzoli Elena, Bi Mark, Buza Natalia, Hui Pei, Wong Serena, Abu-Khalaf Maysa, Ravaggi Antonella, Bignotti Eliana, Bandiera Elisabetta, Romani Chiara, Todeschini Paola, Tassi Renata, Zanotti Laura, Odicino Franco, Pecorelli Sergio, Donzelli Carla, Ardighieri Laura, Facchetti Fabio, Falchetti Marcella, Silasi Dan-Arin, Ratner Elena, Azodi Masoud, Schwartz Peter E, Mane Shrikant, Angioli Roberto, Terranova Corrado, Quick Charles Matthew, Edraki Babak, Bilgüvar Kaya, Lee Moses, Choi Murim, Stiegler Amy L, Boggon Titus J, Schlessinger Joseph, Lifton Richard P, Santin Alessandro D
Abstract excerpt
Carcinosarcomas (CSs) of the uterus and ovary are highly aggressive neoplasms containing both carcinomatous and sarcomatous elements. We analyzed the mutational landscape of 68 uterine and ovarian CSs by whole-exome sequencing. We also performed multiregion whole-exome sequencing comprising two carcinoma and sarcoma samples from six tumors to resolve their evolutionary histories. The results demonstrated that...
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