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Article

Whole genome sequencing analysis of over 3500 individuals dementia-free over 85 years old.

Journal of Alzheimer's disease : JAD - 1 Jun 2026

Peloso Gina M, Wang Dongyu, Abbruzzese Sabrina M, Bis Joshua C, Choi Seung Hoan, Beiser Alexa, Bressler Jan, Dupuis Josée, Fohner Alison E, Ghanbari Mohsen, Gibbs Richard A, Heard-Costa Nancy, Ikram M Arfan, Lacaze Paul, Le Grand Quentin, Lopez Oscar L, Mosley Thomas H, Riaz Moeen, Soumaré Aïcha, Yaqub Amber, Boerwinkle Eric, Psaty Bruce M, Fornage Myriam, Seshadri Sudha, DeStefano Anita L

Abstract excerpt

BackgroundIdentifying genetic variants conferring resilience to Alzheimer's disease and related dementia (ADRD) may hold promise for developing therapeutics.ObjectiveTo determine genetic associations with being dementia-free at age 85 (DF85).MethodsWe examined genetic associations, using whole genome sequencing data, with DF85 in three Trans-Omics for Precision Medicine cohorts and the Alzheimer's Disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42024100
DOI: 10.1177/13872877261444302
PMCID: PMC13162269

Genes

MAF
APOE
GCH1
MAL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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