Article
Whole exome sequencing analyses identified novel genes for Alzheimer's disease and related dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2024
Zhang Ya-Ru, Wu Bang-Sheng, Chen Shi-Dong, Yang Liu, Deng Yue-Ting, Guo Yu, Wu Xin-Rui, Liu Wei-Shi, Kang Ju-Jiao, Feng Jian-Feng, Cheng Wei, Yu Jin-Tai
Abstract excerpt
INTRODUCTION: The heritability of Alzheimer's disease (AD) is estimated to be 58%-79%. However, known genes can only partially explain the heritability. METHODS: Here, we conducted gene-based exome-wide association study (ExWAS) of rare variants and single-variant ExWAS of common variants, utilizing data of 54,569 clinically diagnosed/proxy AD and related dementia (ADRD) and 295,421 controls from the UK Biobank....
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