Article
Genetic testing of common and rare variants in dementia patients from a memory clinic : Dementia-related genetic testing in memory clinic.
Alzheimer's research & therapy - 14 Oct 2025
de Rojas Itziar, Hulsman Marc, Tesi Niccoló, van Spaendonk Rosalina M L, van der Schaar Jetske, Dijkstra Janna I R, van der Flier Wiesje M, van Ruissen Fred, Jansen Philip R, Reinders Marcel T, van Haelst Mieke M, Pijnenburg Yolande A L, Fernandez Maria Victoria, Ruiz Agustín, Holstege Henne H, van der Lee Sven J
Abstract excerpt
BACKGROUND: Many types of dementia have high heritability, which creates opportunities for DNA diagnostics. Clinicians sporadically test for causal genetic variants. However, in addition to causal genetic mutations, an increasing number of both common and rare risk factors are being identified, especially for Alzheimer’s disease (AD). Here, we describe and evaluate diagnostic performance of combining genetic risk...
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