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Article

Multi-ancestry exome-wide study identifies variants associated with Alzheimer's disease protection.

Journal of Alzheimer's disease : JAD - 1 Feb 2026

Khurshid Zainab, Farrell John J, Tong Tong, Zhu Congcong, Martin Eden R, Bush Will, Pericak-Vance Margaret A, Wang Li-San, Schellenberg Gerard, Haines Jonathan L, Lunetta Kathryn L, Leung Yuk Yee, Zhang Xiaoling, Farrer Lindsay A

Abstract excerpt

BackgroundPrevious whole exome and whole genome sequencing (WES/WGS) studies identified genome-wide significant associations for late-onset Alzheimer's disease (AD) with rare variants but highlighted the need for larger samples.ObjectiveIdentify associations of rare coding variants with AD risk in a large-scale, multi-ancestry exome-wide.MethodsWe combined non-overlapping portions of the Alzheimer's Disease...

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Identifiers

PMID: 41428483
DOI: 10.1177/13872877251405497
PMCID: PMC13189266

Genes

ADCY4
APOE
BTBD8
DYNLT4
KCNG2
PSEN1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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