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Article

Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

10 Jun 2019

Abstract excerpt

IMPORTANCE: Previous genome-wide association studies of common variants identified associations for Alzheimer disease (AD) loci evident only among individuals with particular APOE alleles. OBJECTIVE: To identify APOE genotype-dependent associations with infrequent and rare variants using whole-exome sequencing. DESIGN, SETTING, AND PARTICIPANTS: The discovery stage included 10 441 non-Hispanic white participants...

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PMID: 31180460
DOI: 10.1001/jamaneurol.2019.1456

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