An atlas of epithelial cell states and plasticity in lung adenocarcinoma.

doi:10.1038/s41586-024-07113-9

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Article

An atlas of epithelial cell states and plasticity in lung adenocarcinoma.

Nature - 1 Mar 2024

Han Guangchun, Sinjab Ansam, Rahal Zahraa, Lynch Anne M, Treekitkarnmongkol Warapen, Liu Yuejiang, Serrano Alejandra G, Feng Jiping, Liang Ke, Khan Khaja, Lu Wei, Hernandez Sharia D, Liu Yunhe, Cao Xuanye, Dai Enyu, Pei Guangsheng, Hu Jian, Abaya Camille, Gomez-Bolanos Lorena I, Peng Fuduan, Chen Minyue, Parra Edwin R, Cascone Tina, Sepesi Boris, Moghaddam Seyed Javad, Scheet Paul, Negrao Marcelo V, Heymach John V, Li Mingyao, Dubinett Steven M, Stevenson Christopher S, Spira Avrum E, Fujimoto Junya, Solis Luisa M, Wistuba Ignacio I, Chen Jichao, Wang Linghua, Kadara Humam

Abstract excerpt

Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies1. Here we studied 246,102 single epithelial cells from 16 early-stage LUADs and 47 matched normal lung samples. Epithelial cells comprised diverse normal and cancer cell states, and diversity among cancer cells was strongly linked to LUAD-specific oncogenic drivers. KRAS...

Topics

Animals
Humans
Mice
Adenocarcinoma of Lung
Alveolar Epithelial Cells
Aneuploidy
Carcinogens
Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epithelial Cells

Lung Neoplasms

Mutation

Organoids

Precancerous Conditions

Proto-Oncogene Proteins p21(ras)

Survival Rate

Tobacco Products

Keratin-8

Source

Open in PubMed Open full text

Identifiers

PMID: 38418883
DOI: 10.1038/s41586-024-07113-9
PMCID: PMC10954546

Genes

KRAS
KRT8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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