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Article

Gene editing of the GJB2 locus in porcine embryos using CRISPR/Cas9 and cytosine base editors: toward a model of congenital deafness.

Scientific reports - 18 Apr 2026

Piñeiro-Silva Celia, Bermejo-Álvarez Pablo, García-Purriños Francisco José, Gadea Joaquín

Abstract excerpt

Mutations in the GJB2 gene, which encodes Connexin 26 (Cx26), are responsible for the majority of cases of non-syndromic congenital hearing loss in humans. While murine GJB2 knockout models have provided mechanistic insight, anatomical and physiological differences limit their translational relevance. Pigs represent a valuable large-animal model because their auditory anatomy and maturation closely resemble those...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42000863
DOI: 10.1038/s41598-026-49229-0
PMCID: PMC13250082

Genes

GJB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Gene editing of the GJB2 locus in porcine embryos using CRISPR/Cas9 and cytosine base editors: toward a model of congenital deafness.PMID 42000863Read ↗

Generation of GJB2 Gene-Edited Porcine Embryos as a Model for Human Congenital Deafness via CRISPR/Cas9 and Cytosine base editorsSemantic proximity Read ↗

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