Article
Effective generation of maternal genome point mutated porcine embryos by injection of cytosine base editor into germinal vesicle oocytes.
Science China. Life sciences - 1 Jul 2020
Su Xiaohu, Chen Wei, Cai Qingqing, Liang Puping, Chen Yaosheng, Cong Peiqing, Huang Junjiu
Abstract excerpt
Cytosine and adenine base editors are promising new tools for introducing precise genetic modifications that are required to generate disease models and to improve traits in pigs. Base editors can catalyze the conversion of C→T (C>T) or A→G (A>G) in the target site through a single guide RNA. Injection of base editors into the zygote cytoplasm can result in the production of offspring with precise point...
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